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Compound Detail

CHEMBL1201073

SUCCIMER
💊 Approved Drug
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💊 Approved Drug
O=C(O)[C@@H](S)[C@@H](S)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201073
Name SUCCIMER
Phase Approved
Structure Type MOL
InChI Key ACTRVOBWPAIOHC-XIXRPRMCSA-N
Therapeutic ✓ Yes

Known Names

Chemet DIM-SA DMS-A DMSA Meso-2,3-dimercaptosuccinic acid RO 1-7977 Succimer Succimero
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
8
Known Names
6
Indications
1
Mechanisms

Molecular Properties

182.2
MW (Da)
-0.25
ALogP
4
HBA
4
HBD
74.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1991
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product
USAN Stem -mer
USAN Year 1978

Extended Properties

Molecular Formula C4H6O4S2
MW 182.22
Aromatic Rings 0
Heavy Atoms 10
NP-Likeness 0.24

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Lead chelating agent CHELATING AGENT Lead ✓ ✓

Indications

Asperger Syndrome Autistic Disorder Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukemia, Myeloid, Acute Myelodysplastic Syndromes Hepatolenticular Degeneration

Activity Summary

IC50 1 meas. best 5.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Replicase polyprotein 1ab
CHEMBL4523582
 IC50 5.76 5.76 1720.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Replicase polyprotein 1ab IC50 = 1720.0 nM 5.76 SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response ... -

Literature References

PubMed DOI Target Context # Activities
16472241 10.2174/1570163043334794 Hepatotoxicity 18
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 5
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
30852084 10.1016/j.bmcl.2019.02.028 GroEL/GroES 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Bile salt export pump 1
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
- 10.6019/EOS300044 Replicase polyprotein 1ab 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1

Data from ChEMBL 36 via Core Engine