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Compound Detail

CHEMBL1201891

DEFLAZACORT
💊 Approved Drug
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💊 Approved Drug
CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201891
Name DEFLAZACORT
Phase Approved
Structure Type MOL
InChI Key FBHSPRKOSMHSIF-GRMWVWQJSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL5315131

Known Names

Azacortinol Calcort Deflazacort DL-458IT Emflaza L-5458 MDL 458 MDL-458 MDL458 Zamene
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
10
Known Names
7
Indications
1
Mechanisms

Molecular Properties

441.5
MW (Da)
2.56
ALogP
7
HBA
1
HBD
102.3
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2017
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product First in Class Prodrug
USAN Year 1986

Extended Properties

Molecular Formula C25H31NO6
MW 441.52
Aromatic Rings 0
Heavy Atoms 32
NP-Likeness 2.04

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Glucocorticoid receptor agonist AGONIST Glucocorticoid receptor ✓ ✓

Indications

Muscular Dystrophies Muscular Dystrophies Muscular Dystrophy, Duchenne Muscular Dystrophies, Limb-Girdle Aspergillosis, Allergic Bronchopulmonary Kidney Diseases Liver Diseases

ATC Classification

H02AB13
deflazacort
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: CORTICOSTEROIDS FOR SYSTEMIC USE

Literature References

PubMed DOI Target Context # Activities
- 10.5281/zenodo.13943903 ADMET 89
27010501 10.1016/j.bmc.2016.03.024 Mus musculus 8
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 3
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1

Data from ChEMBL 36 via Core Engine