Compound Detail
CHEMBL1215485
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Basic Information
| ChEMBL ID | CHEMBL1215485 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHNSKVYWFDVXHV-GMAHTHKFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
385.5
MW (Da)
4.60
ALogP
4
HBA
1
HBD
76.7
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mineralocorticoid receptor CHEMBL1994 | IC50 | 7.05 | 7.05 | 89.0 | 1 |
| Progesterone receptor CHEMBL208 | IC50 | 5.5 | 5.5 | 3180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | IC50 | = | 89.0 | nM | 7.05 | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human... | 20672822 |
| Progesterone receptor | IC50 | = | 3180.0 | nM | 5.5 | Antagonist activity at progesterone receptor | 20672822 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20672822 | 10.1021/jm100505n | Unchecked | 2 |
| 20672822 | 10.1021/jm100505n | Androgen receptor | 1 |
| 20672822 | 10.1021/jm100505n | Mineralocorticoid receptor | 1 |
| 20672822 | 10.1021/jm100505n | Progesterone receptor | 1 |
| 20672822 | 10.1021/jm100505n | Estrogen receptor | 1 |
| 20672822 | 10.1021/jm100505n | Glucocorticoid receptor | 1 |
Data from ChEMBL 36 via Core Engine