Compound Detail
CHEMBL121918
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CCOc1nn(-c2ccc(C)c(C)c2)c(O)c1/N=N/c1c(O)cc(S(=O)(=O)O)c2ccccc12
Basic Information
| ChEMBL ID | CHEMBL121918 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AZJLPOMBLDBEII-OCOZRVBESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
482.5
MW (Da)
5.11
ALogP
9
HBA
3
HBD
146.6
PSA (Ų)
0.26
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 6.22 | 6.22 | 600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 600.0 | nM | 6.22 | Effective concentration for thrombopoietin luciferase activity was determined in... | 11606138 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11606138 | 10.1021/jm010283l | Thrombopoietin receptor | 2 |
Data from ChEMBL 36 via Core Engine