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Assay Detail

CHEMBL815867

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type BaF3
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thrombopoietin receptor (CHEMBL1864) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
Duffy KJ, Darcy MG, Delorme E, Dillon SB, Eppley DF, Erickson-Miller C, Giampa L, Hopson CB, Huang Y, Keenan RM, Lamb P, Leong L, Liu N, Miller SG, Price AT, Rosen J, Shah R, Shaw TN, Smith H, Stark KC, Tian SS, Tyree C, Wiggall KJ, Zhang L, Luengo JI.
J Med Chem (2001) 44 : 3730 -3745
PubMed 11606138 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 45 6.13 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3144775 — — 1 7.70
CHEMBL3144844 — — 1 7.40
CHEMBL3144661 — — 1 7.40
CHEMBL3144783 — — 1 7.16
CHEMBL3144778 — — 1 7.16
CHEMBL420168 — — 1 7.16
CHEMBL3144666 — — 1 7.00
CHEMBL3144784 — — 1 7.00
CHEMBL124855 — — 1 6.70
CHEMBL3144680 — — 1 6.70
CHEMBL124367 — — 1 6.70
CHEMBL3144672 — — 1 6.70
CHEMBL3144664 — — 1 6.70
CHEMBL123373 — — 1 6.52
CHEMBL3144662 — — 1 6.52
CHEMBL3144670 — — 1 6.52
CHEMBL3144781 — — 1 6.52
CHEMBL3144682 — — 1 6.40
CHEMBL3144776 — — 1 6.30
CHEMBL121918 — — 1 6.22
CHEMBL3144786 — — 1 6.16
CHEMBL3144790 — — 1 6.05
CHEMBL3144677 — — 1 6.00
CHEMBL3144780 — — 1 5.70
CHEMBL3144852 — — 1 5.70
CHEMBL3144787 — — 1 5.70
CHEMBL3144789 — — 1 5.70
CHEMBL121996 — — 1 5.70
CHEMBL3144663 — — 1 5.70
CHEMBL3144785 — — 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3144775 — EC50 = 20.0 nM 7.70
CHEMBL3144844 — EC50 = 40.0 nM 7.40
CHEMBL3144661 — EC50 = 40.0 nM 7.40
CHEMBL3144783 — EC50 = 70.0 nM 7.16
CHEMBL3144778 — EC50 = 70.0 nM 7.16
CHEMBL420168 — EC50 = 70.0 nM 7.16
CHEMBL3144666 — EC50 = 100.0 nM 7.00
CHEMBL3144784 — EC50 = 100.0 nM 7.00
CHEMBL3144664 — EC50 = 200.0 nM 6.70
CHEMBL3144672 — EC50 = 200.0 nM 6.70
CHEMBL124367 — EC50 = 200.0 nM 6.70
CHEMBL3144680 — EC50 = 200.0 nM 6.70
CHEMBL124855 — EC50 = 200.0 nM 6.70
CHEMBL3144781 — EC50 = 300.0 nM 6.52
CHEMBL3144670 — EC50 = 300.0 nM 6.52
CHEMBL123373 — EC50 = 300.0 nM 6.52
CHEMBL3144662 — EC50 = 300.0 nM 6.52
CHEMBL3144682 — EC50 = 400.0 nM 6.40
CHEMBL3144776 — EC50 = 500.0 nM 6.30
CHEMBL121918 — EC50 = 600.0 nM 6.22
CHEMBL3144786 — EC50 = 700.0 nM 6.16
CHEMBL3144790 — EC50 = 900.0 nM 6.05
CHEMBL3144677 — EC50 = 1000.0 nM 6.00
CHEMBL3144852 — EC50 = 2000.0 nM 5.70
CHEMBL3144787 — EC50 = 2000.0 nM 5.70
CHEMBL3144789 — EC50 = 2000.0 nM 5.70
CHEMBL121996 — EC50 = 2000.0 nM 5.70
CHEMBL3144663 — EC50 = 2000.0 nM 5.70
CHEMBL3144785 — EC50 = 2000.0 nM 5.70
CHEMBL122504 — EC50 = 2000.0 nM 5.70
CHEMBL125996 — EC50 = 2000.0 nM 5.70
CHEMBL3144780 — EC50 = 2000.0 nM 5.70
CHEMBL340040 — EC50 = 3000.0 nM 5.52
CHEMBL3144788 — EC50 = 3000.0 nM 5.52
CHEMBL122867 — EC50 = 3000.0 nM 5.52
CHEMBL445374 — EC50 = 5000.0 nM 5.30
CHEMBL3144668 — EC50 = 5000.0 nM 5.30
CHEMBL3144675 — EC50 = 5000.0 nM 5.30
CHEMBL3144676 — EC50 = 7000.0 nM 5.16
CHEMBL3144836 — EC50 = 8000.0 nM 5.10
CHEMBL331220 — EC50 = 10000.0 nM 5.00
CHEMBL3144665 — EC50 = 10000.0 nM 5.00
CHEMBL3144667 — EC50 = 10000.0 nM 5.00
CHEMBL3144669 — EC50 > 30000.0 nM -
CHEMBL3144679 — EC50 > 30000.0 nM -