Compound Detail
CHEMBL3144778
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Cc1[nH]n(-c2cccc(C(C)(C)C)c2)c(=O)c1/N=N/c1c(O)cc(S(=O)(=O)O)c2ccccc12
Basic Information
| ChEMBL ID | CHEMBL3144778 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VLPJANNHBCOCKM-OCEACIFDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
5.29
ALogP
7
HBA
3
HBD
137.1
PSA (Ų)
0.27
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 70.0 | nM | 7.16 | Effective concentration for thrombopoietin luciferase activity was determined in... | 11606138 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11606138 | 10.1021/jm010283l | Thrombopoietin receptor | 2 |
Data from ChEMBL 36 via Core Engine