Compound Detail
CHEMBL1221711
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Basic Information
| ChEMBL ID | CHEMBL1221711 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | KAJAOGBVWCYGHZ-JTQLQIEISA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
279.3
MW (Da)
-1.13
ALogP
4
HBA
4
HBD
121.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 15 member 2 CHEMBL3325 | Ki | 4.54 | 4.54 | 29000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 15 member 2 | Ki | = | 29000.0 | nM | 4.54 | TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells | 11007306 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9190878 | - | Solute carrier family 15 member 1 | 2 |
| 10691692 | 10.1021/jm990226g | Tripeptidyl-peptidase 2 | 1 |
| 19060912 | 10.1038/nchembio.132 | General amino-acid permease GAP1 | 1 |
| 11007306 | 10.1007/s004240000339 | Solute carrier family 15 member 2 | 1 |
| 11007306 | 10.1007/s004240000339 | Solute carrier family 15 member 1 | 1 |
Data from ChEMBL 36 via Core Engine