Compound Detail
CHEMBL1222014
2H LACTIMIDOMYCIN K Enter ChEMBL ID:
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C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)NC(=O)C1)[C@@H]1OC(=O)CCCC/C=C/C=C\[C@@H]1C
Basic Information
| ChEMBL ID | CHEMBL1222014 |
| Name | 2H LACTIMIDOMYCIN K |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNCFXSXKMXNDOK-CDGPMMGTSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
459.6
MW (Da)
3.57
ALogP
6
HBA
2
HBD
109.8
PSA (Ų)
0.34
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HeLa CHEMBL399 | IC50 | 7.01 | 7.01 | 98.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HeLa | IC50 | = | 98.47 | nM | 7.01 | Inhibition of protein synthesis in human HeLa cells assessed as [35S]cysteine/me... | 20118940 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20118940 | 10.1038/nchembio.304 | HeLa | 3 |
| 20118940 | 10.1038/nchembio.304 | MDA-MB-231 | 1 |
| 20118940 | 10.1038/nchembio.304 | Jurkat | 1 |
Data from ChEMBL 36 via Core Engine