Compound Detail
CHEMBL1235713
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Basic Information
| ChEMBL ID | CHEMBL1235713 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NSHBSERFNQQOCC-JOCQHMNTSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
373.8
MW (Da)
3.40
ALogP
5
HBA
3
HBD
90.4
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | Kd | 7.5 | 7.5 | 32.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | Kd | = | 32.0 | nM | 7.5 | Inhibition of p38alpha | 21375264 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21375264 | 10.1021/jm101423y | Tyrosine-protein kinase Lck | 1 |
| 21375264 | 10.1021/jm101423y | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine