Compound Detail
CHEMBL123679
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Basic Information
| ChEMBL ID | CHEMBL123679 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCELNBAHYXGUKT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
407.6
MW (Da)
4.68
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | IC50 | 7.54 | 7.54 | 28.6 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 6.31 | 6.31 | 486.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | IC50 | = | 28.6 | nM | 7.54 | Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-del... | 11052793 |
| Mu-type opioid receptor | IC50 | = | 486.0 | nM | 6.31 | Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 a... | 11052793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11052793 | 10.1021/jm000228x | Delta-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Mu-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Kappa-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Opioid receptors; mu & delta | 1 |
Data from ChEMBL 36 via Core Engine