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Compound Detail

CHEMBL1259076

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CCCCCCC1(c2cc(O)c3c(c2)OC(C)(C)[C@@H]2CC[C@@H](O)C[C@@H]32)CCC1

Basic Information

ChEMBL ID CHEMBL1259076
Phase Preclinical
Structure Type MOL
InChI Key CSXKNESDVLECTJ-VAMGGRTRSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

386.6
MW (Da)
6.20
ALogP
3
HBA
2
HBD
49.7
PSA (Ų)
0.57
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H38O3
MW 386.58
Aromatic Rings 1
Heavy Atoms 28
NP-Likeness 2.11

Activity Summary

Ki 4 meas. best 9.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL3571
Ki 9.8 9.8 0.2 2
Cannabinoid receptor 2
CHEMBL5373
Ki 8.38 8.38 4.2 1
Cannabinoid receptor 2
CHEMBL253
Ki 8.29 8.29 5.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20925434 10.1021/jm100641g Cannabinoid receptor 2 2
20925434 10.1021/jm100641g Cannabinoid receptor 1 1
20925434 10.1021/jm100641g Unchecked 1
20925434 10.1021/jm100641g Rattus norvegicus 1
35051750 10.1016/j.ejmech.2021.114027 Cannabinoid receptor 1 1

Data from ChEMBL 36 via Core Engine