Compound Detail
CHEMBL12696
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O=C(O)Cn1c(=O)c(=O)[nH]c2cc(C(F)(F)F)c(-n3ccc(CNC(=O)Nc4ccc(Br)cc4)c3)cc21
Basic Information
| ChEMBL ID | CHEMBL12696 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YXQUINDTMKETDY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
580.3
MW (Da)
3.67
ALogP
6
HBA
4
HBD
138.2
PSA (Ų)
0.26
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | Ki | 8.4 | 8.4 | 4.0 | 1 |
| Glutamate receptor ionotropic kainate CHEMBL2109241 | Ki | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA | Ki | = | 4.0 | nM | 8.4 | Displacement of [3H]AMPA from AMPA receptor | - |
| Glutamate receptor ionotropic kainate | Ki | = | 110.0 | nM | 6.96 | Ability to displace [3H]kainate from kainate receptor | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00170-4 | Glutamate receptor ionotropic AMPA | 1 |
| - | 10.1016/S0960-894X(97)00170-4 | Glutamate receptor ionotropic, NMDA 2C | 1 |
| - | 10.1016/S0960-894X(97)00170-4 | Glutamate receptor ionotropic kainate | 1 |
| - | 10.1016/S0960-894X(97)00170-4 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine