Assay Detail
Binding
CHEMBL644195
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Displacement of [3H]AMPA from AMPA receptor
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Pyrrolylquinoxalinediones: The importance of pyrrolic substitution on AMPA receptor binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.62 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12696 | — | — | 1 | 8.40 |
| CHEMBL13076 | — | — | 1 | 8.30 |
| CHEMBL273675 | — | — | 1 | 8.30 |
| CHEMBL12510 | — | — | 1 | 7.82 |
| CHEMBL12989 | — | — | 1 | 7.31 |
| CHEMBL268284 | — | — | 1 | 7.16 |
| CHEMBL222519 | NBQX | — | 1 | 7.16 |
| CHEMBL12761 | — | — | 1 | 7.15 |
| CHEMBL12358 | — | — | 1 | 7.12 |
| CHEMBL275334 | — | — | 1 | 7.11 |
| CHEMBL13018 | — | — | 1 | 7.02 |
| CHEMBL418535 | — | — | 1 | 6.96 |
| CHEMBL13260 | YM-90K | — | 1 | 6.87 |
| CHEMBL13017 | — | — | 1 | 6.85 |
| CHEMBL12448 | — | — | 1 | 6.75 |
| CHEMBL12747 | — | — | 1 | 6.68 |
| CHEMBL268709 | — | — | 1 | 6.60 |
| CHEMBL12776 | — | — | 1 | 6.60 |
| CHEMBL440455 | — | — | 1 | 6.55 |
| CHEMBL12730 | — | — | 1 | 6.40 |
| CHEMBL276709 | — | — | 1 | 6.30 |
| CHEMBL12841 | — | — | 1 | 6.19 |
| CHEMBL12465 | — | — | 1 | 6.08 |
| CHEMBL12431 | — | — | 1 | 6.06 |
| CHEMBL274219 | — | — | 1 | 6.05 |
| CHEMBL12653 | — | — | 1 | 6.01 |
| CHEMBL276205 | — | — | 1 | 5.70 |
| CHEMBL269684 | — | — | 1 | 5.70 |
| CHEMBL417074 | — | — | 1 | 5.52 |
| CHEMBL12820 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12696 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL13076 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL273675 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL12510 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL12989 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL268284 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL222519 | NBQX | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL12761 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL12358 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL275334 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL13018 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL418535 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL13260 | YM-90K | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL13017 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL12448 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL12747 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL268709 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL12776 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL440455 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL12730 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL276709 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL12841 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL12465 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL12431 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL274219 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL12653 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL269684 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL276205 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL417074 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL12820 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL12715 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL13219 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL273480 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL13176 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL267551 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL12896 | — | Ki | > | 25000.0 | nM | - |