Compound Detail
CHEMBL12820
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Basic Information
| ChEMBL ID | CHEMBL12820 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XWWKWPIMFBOKAY-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
295.2
MW (Da)
2.85
ALogP
5
HBA
2
HBD
71.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2096617 | Ki | 5.52 | 5.52 | 3000.0 | 1 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | Ki | 5.52 | 5.52 | 3000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA | Ki | = | 3000.0 | nM | 5.52 | Displacement of [3H]AMPA from AMPA receptor | - |
| Glutamate receptor ionotropic, AMPA | Ki | = | 3000.0 | nM | 5.52 | Compound was tested for binding affinity against Ionotropic glutamate receptor A... | - |
| Glutamate receptor ionotropic AMPA | Ki | = | 3000.0 | nM | 5.52 | In vitro binding affinity against AMPA receptor by [3H]AMPA displacement. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00170-4 | Glutamate receptor ionotropic AMPA | 1 |
| - | 10.1016/S0960-894X(96)00534-3 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(97)00428-9 | Glutamate receptor ionotropic AMPA | 1 |
Data from ChEMBL 36 via Core Engine