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Compound Detail

CHEMBL12719

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COc1ccc(CC[C@@H](C)NC[C@@H](O)COc2ccc(O)cc2)cc1

Basic Information

ChEMBL ID CHEMBL12719
Phase Preclinical
Structure Type MOL
InChI Key FVXAAPNMRWHMJD-CRAIPNDOSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

345.4
MW (Da)
2.75
ALogP
5
HBA
3
HBD
71.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H27NO4
MW 345.44
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.11

Activity Summary

EC50 2 meas. best 7.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.52 7.52 30.0 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 5.22 5.22 6000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9871716 10.1016/s0960-894x(98)00169-3 Beta-3 adrenergic receptor 1
9871716 10.1016/s0960-894x(98)00169-3 Beta-1 adrenergic receptor 1
9871716 10.1016/s0960-894x(98)00169-3 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine