Compound Detail
CHEMBL1276872
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Basic Information
| ChEMBL ID | CHEMBL1276872 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UDNODFHPGFCRNK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
353.8
MW (Da)
5.23
ALogP
5
HBA
0
HBD
51.8
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 5.38 | 5.38 | 4200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 4200.0 | nM | 5.38 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 20947362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20947362 | 10.1016/j.bmc.2010.09.051 | SGC-7901 | 1 |
| 20947362 | 10.1016/j.bmc.2010.09.051 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine