Compound Detail
CHEMBL1277563
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Basic Information
| ChEMBL ID | CHEMBL1277563 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XIDONAJYIQWYMK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
301.8
MW (Da)
4.30
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 4 CHEMBL1287624 | IC50 | 4.11 | 4.11 | 78000.0 | 1 |
| Lethal(3)malignant brain tumor-like protein 1 CHEMBL1287622 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 4 | IC50 | = | 78000.0 | nM | 4.11 | Inhibition of L3MBTL4 by alpha-screening | 20931980 |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of L3MBTL1 by alpha-screening | 20931980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20931980 | 10.1021/jm1007374 | Lethal(3)malignant brain tumor-like protein 1 | 2 |
| 20931980 | 10.1021/jm1007374 | Lethal(3)malignant brain tumor-like protein 4 | 1 |
| 20931980 | 10.1021/jm1007374 | Lethal(3)malignant brain tumor-like protein 3 | 1 |
| 20931980 | 10.1021/jm1007374 | MBT domain-containing protein 1 | 1 |
Data from ChEMBL 36 via Core Engine