Compound Detail
CHEMBL1278128
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Basic Information
| ChEMBL ID | CHEMBL1278128 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ABJDIBYQJRRITI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
349.8
MW (Da)
3.79
ALogP
7
HBA
1
HBD
81.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 20947362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20947362 | 10.1016/j.bmc.2010.09.051 | SGC-7901 | 1 |
| 20947362 | 10.1016/j.bmc.2010.09.051 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine