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Compound Detail

CHEMBL12864

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CCCCCCNC(=O)Nc1cccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)c1

Basic Information

ChEMBL ID CHEMBL12864
Phase Preclinical
Structure Type MOL
InChI Key FOPZEEYGUUWGID-MHZLTWQESA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

584.7
MW (Da)
4.47
ALogP
7
HBA
6
HBD
149.0
PSA (Ų)
0.13
QED
2
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H40N4O6S
MW 584.74
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -1.16

Activity Summary

EC50 1 meas. best 8.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.34 8.34 4.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Beta-3 adrenergic receptor EC50 = 4.6 nM 8.34 Agonist activity towards human Beta-3 adrenergic receptor 9871717

Literature References

PubMed DOI Target Context # Activities
9871717 10.1016/s0960-894x(98)00170-x Beta-3 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine