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Compound Detail

CHEMBL131819

TAZOMELINE
🧪 Phase II
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🧪 Phase II
CCCCCCSc1nsnc1C1=CCCN(C)C1

Basic Information

ChEMBL ID CHEMBL131819
Name TAZOMELINE
Phase Phase II
Structure Type MOL
InChI Key XUHMGFKQBWZWPO-UHFFFAOYSA-N

Known Names

LY-287041 Tazomelina Tazomeline
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
3
Known Names

Molecular Properties

297.5
MW (Da)
3.93
ALogP
5
HBA
0
HBD
29.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Stem -meline
USAN Year 1997

Extended Properties

Molecular Formula C14H23N3S2
MW 297.49
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.59

Activity Summary

IC50 3 meas. best 8.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 8.3 8.245 5.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1433209 10.1021/jm00100a005 Muscarinic acetylcholine receptor M1 4

Data from ChEMBL 36 via Core Engine