Compound Detail
CHEMBL1319383
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Basic Information
| ChEMBL ID | CHEMBL1319383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDOQBQRIEWHWBT-GSVOUGTGSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
183.1
MW (Da)
-1.03
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.89
IC50 2 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 6.89 | 6.89 | 130.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 6.54 | 6.54 | 290.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL3842 | EC50 | 5.99 | 5.99 | 1030.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 130.0 | nM | 6.89 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 8 | EC50 | = | 290.0 | nM | 6.54 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 6 | EC50 | = | 1030.0 | nM | 5.99 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1469691 | 10.1021/jm00102a014 | Rattus norvegicus | 3 |
Data from ChEMBL 36 via Core Engine