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Compound Detail

CHEMBL1323355

DEXTROMEPROMAZINE
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COc1ccc2c(c1)N(C[C@@H](C)CN(C)C)c1ccccc1S2
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1323355
Name DEXTROMEPROMAZINE
Phase Preclinical
Structure Type MOL
InChI Key VRQVVMDWGGWHTJ-AWEZNQCLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

328.5
MW (Da)
4.50
ALogP
4
HBA
0
HBD
15.7
PSA (Ų)
0.80
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C19H24N2OS
MW 328.48
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -1.00

Activity Summary

IC50 1 meas. best 5.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Pleiotropic ABC efflux transporter of multiple drugs
CHEMBL1697658
 IC50 5.05 5.05 9000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Pleiotropic ABC efflux transporter of multiple drugs IC50 = 9000.0 nM 5.05 Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae ... 19188399

Literature References

PubMed DOI Target Context # Activities
19188399 10.1128/aac.00956-08 Pleiotropic ABC efflux transporter of multiple drugs 2
19188399 10.1128/aac.00956-08 Snq2p 1
19188399 10.1128/aac.00956-08 Unchecked 1

Data from ChEMBL 36 via Core Engine