Compound Detail
CHEMBL1324227
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N#Cc1ccc(N2C(=O)[C@@H]3C(C(=O)c4ccc5ccccc5n4)=NN[C@@H]3C2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL1324227 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XZQXLMOGBXORHQ-MJGOQNOKSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
395.4
MW (Da)
1.81
ALogP
7
HBA
1
HBD
115.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endoribonuclease toxin MazF CHEMBL1795096 | EC50 | 6.57 | 5.5 | 271.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endoribonuclease toxin MazF | EC50 | = | 271.0 | nM | 6.57 | PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... | - |
| Endoribonuclease toxin MazF | EC50 | = | 7740.0 | nM | 5.11 | PUBCHEM_BIOASSAY: SAR analysis of small molecule activators of the MazEF TA Syst... | - |
| Endoribonuclease toxin MazF | EC50 | = | 15100.0 | nM | 4.82 | PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... | - |
Data from ChEMBL 36 via Core Engine