Compound Detail
CHEMBL1324820
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Basic Information
| ChEMBL ID | CHEMBL1324820 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJUOJTBPBKGQGN-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
352.4
MW (Da)
3.44
ALogP
7
HBA
2
HBD
96.5
PSA (Ų)
0.33
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.36
EC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Signal transducer and activator of transcription 1-alpha/beta CHEMBL6101 | IC50 | 5.36 | 5.14 | 4363.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Signal transducer and activator of transcription 1-alpha/beta | IC50 | = | 4363.0 | nM | 5.36 | PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT1 inhibition. (C... | - |
| Signal transducer and activator of transcription 1-alpha/beta | IC50 | = | 12169.0 | nM | 4.92 | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28689975 | 10.1016/j.bmc.2017.06.049 | Unchecked | 1 |
| 28689975 | 10.1016/j.bmc.2017.06.049 | Chikungunya virus | 1 |
| 28689975 | 10.1016/j.bmc.2017.06.049 | Vero | 1 |
Data from ChEMBL 36 via Core Engine