Compound Detail
CHEMBL134291
6-METHYLFLAVONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL134291 |
| Name | 6-METHYLFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NOQJBXPAMJLUSS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
236.3
MW (Da)
3.77
ALogP
2
HBA
0
HBD
30.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 6.9 | 6.825 | 125.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 125.0 | nM | 6.9 | In vitro affinity against Benzodiazepine receptor binding to rat cortical membra... | 10543878 |
| GABA-A receptor; anion channel | Ki | = | 180.0 | nM | 6.75 | Ability to inhibit [3H]-Ro- 15-1788 binding to Gamma-aminobutyric acid A recepto... | 12213060 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10543878 | 10.1021/jm991010h | GABA-A receptor; anion channel | 2 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Glucocorticoid receptor | 2 |
| 20415424 | 10.1021/jf100073j | Spodoptera frugiperda | 2 |
| 28408221 | 10.1016/j.bmcl.2017.03.057 | RAW264.7 | 2 |
| 12213060 | 10.1021/jm020839k | GABA-A receptor; anion channel | 1 |
| 18158201 | 10.1016/j.ejmech.2007.11.009 | Unchecked | 1 |
| 19719119 | 10.1021/jm900199u | Aryl hydrocarbon receptor | 1 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Androgen receptor | 1 |
| - | 10.1007/s00044-011-9701-6 | SMMC-7721 | 1 |
| - | 10.1007/s00044-011-9701-6 | HepG2 | 1 |
| 12517100 | 10.1021/jf025627a | Spodoptera litura | 1 |
| 24116873 | 10.1021/jm401463y | Poly [ADP-ribose] polymerase tankyrase-1 | 1 |
Data from ChEMBL 36 via Core Engine