Compound Detail
CHEMBL134345
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL134345 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IQWCBYSUUOFOMF-UUOLZROSSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
193.2
MW (Da)
0.85
ALogP
4
HBA
0
HBD
48.6
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 6.85 | 6.4 | 140.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 140.0 | nM | 6.85 | In vitro affinity evaluated using [3H]- oxotremorine as radioligand in rat cereb... | 9435896 |
| Muscarinic acetylcholine receptor | IC50 | = | 1130.0 | nM | 5.95 | In vitro affinity evaluated using [3H]- quinuclidinyl benzilate as radioligand i... | 9435896 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9435896 | 10.1021/jm9702903 | Rattus norvegicus | 3 |
| 9435896 | 10.1021/jm9702903 | Muscarinic acetylcholine receptor | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 9435896 | 10.1021/jm9702903 | Muscarinic acetylcholine receptor M1 | 1 |
Data from ChEMBL 36 via Core Engine