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Compound Detail

CHEMBL1355299

SULFAETHIDOLE
🧪 Phase II
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🧪 Phase II
CCc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1355299
Name SULFAETHIDOLE
Phase Phase II
Structure Type MOL
InChI Key SVYBEBLNQGDRHF-UHFFFAOYSA-N

Known Names

Sul-spansion Sulfaethidole Sulfaetidol
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names

Molecular Properties

284.4
MW (Da)
1.48
ALogP
6
HBA
2
HBD
98.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem sulfa-

Extended Properties

Molecular Formula C10H12N4O2S2
MW 284.37
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -2.34

Activity Summary

Kd 1 meas. best 5.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
RAC-alpha serine/threonine-protein kinase
CHEMBL4282
 Kd 5.11 5.11 7760.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
RAC-alpha serine/threonine-protein kinase Kd = 7760.0 nM 5.11 SPR Competitive Binding Assay: SPR interaction analyses were performed with a Bi... -

Literature References

PubMed DOI Target Context # Activities
21353784 10.1016/j.bmc.2011.01.049 RAC-alpha serine/threonine-protein kinase 1
21353784 10.1016/j.bmc.2011.01.049 BXPC-3 1
576620 10.1021/jm00213a022 Albumin 1

Data from ChEMBL 36 via Core Engine