Compound Detail
CHEMBL1359
ERTAPENEM 💊 Approved Drug
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💊 Approved Drug
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]12
Basic Information
| ChEMBL ID | CHEMBL1359 |
| Name | ERTAPENEM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JUZNIMUFDBIJCM-ANEDZVCMSA-N |
| Therapeutic | ✓ Yes |
0
Targets
0
Activities
0
Assay Types
20
PK Parameters
20
Publications
1
Known Names
13
Indications
3
Mechanisms
Molecular Properties
475.5
MW (Da)
0.94
ALogP
7
HBA
5
HBD
156.3
PSA (Ų)
0.36
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2001 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial penicillin-binding protein inhibitor | INHIBITOR | Bacterial penicillin-binding protein | ✓ | ✓ |
| Peptidoglycan D,D-transpeptidase FtsI inhibitor | INHIBITOR | Peptidoglycan D,D-transpeptidase FtsI | ✓ | ✓ |
| Cell shape peptidoglycan synthetase penicillin-binding protein 2 inhibitor | INHIBITOR | Cell shape peptidoglycan synthetase penicillin-binding protein 2 | ✓ | ✓ |
Indications
Bacterial Infections Diabetic Foot Gonorrhea Infections Osteomyelitis Pneumonia Urinary Tract Infections Appendicitis Pyelonephritis Renal Insufficiency, Chronic Tuberculosis Tuberculosis, Pulmonary Endometritis
ATC Classification
J01DH03
ertapenem
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 4232.13 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 3728.08 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 228.25 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 185.45 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 3.8 | L/hr | Homo sapiens |
| CL | 0.45 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 241840.51 | nM | Homo sapiens |
| Cmax | 90427.32 | nM | Homo sapiens |
| F | 0.65 | % | Rattus norvegicus |
| F | 0.53 | % | Rattus norvegicus |
| Fu | 0.1 | - | Homo sapiens |
| MRT | 4.4 | hr | Homo sapiens |
| T1/2 | 3.9 | hr | Homo sapiens |
| T1/2 | 5.4 | hr | Homo sapiens |
| T1/2 | 5.0 | hr | Homo sapiens |
| T1/2 | 5.0 | hr | Macaca mulatta |
| T1/2 | 3.8 | hr | Homo sapiens |
| T1/2 | 4.0 | hr | Homo sapiens |
| Tmax | 0.5 | hr | Homo sapiens |
| Tmax | 2.7 | hr | Homo sapiens |
Literature References
Data from ChEMBL 36 via Core Engine