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Compound Detail

CHEMBL136920

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CO/N=C/C12CCCN(CC1)C2

Basic Information

ChEMBL ID CHEMBL136920
Phase Preclinical
Structure Type MOL
InChI Key AXTFXODEYZGKKF-JXMROGBWSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

168.2
MW (Da)
1.10
ALogP
3
HBA
0
HBD
24.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H16N2O
MW 168.24
Aromatic Rings 0
Heavy Atoms 12
NP-Likeness 0.68

Activity Summary

IC50 4 meas. best 7.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.22 6.25 60.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80532-6 Muscarinic acetylcholine receptor 3
9435896 10.1021/jm9702903 Muscarinic acetylcholine receptor 2
9435896 10.1021/jm9702903 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine