Compound Detail
CHEMBL1370278
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Basic Information
| ChEMBL ID | CHEMBL1370278 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YJVWZPHTRDHQJX-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
368.9
MW (Da)
4.99
ALogP
3
HBA
2
HBD
62.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.05
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 5.05 | 5.05 | 8933.0 | 1 |
| SUMO-activating enzyme CHEMBL2095174 | IC50 | 5.0 | 5.0 | 9960.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 8933.0 | nM | 5.05 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Confirmation at Dose to Identify Trans... | - |
| SUMO-activating enzyme | IC50 | = | 9960.0 | nM | 5.0 | PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35978701 | 10.1021/acsmedchemlett.2c00249 | Daoy | 1 |
| 35978701 | 10.1021/acsmedchemlett.2c00249 | A-375 | 1 |
| 35978701 | 10.1021/acsmedchemlett.2c00249 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine