Compound Detail
CHEMBL142619
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Basic Information
| ChEMBL ID | CHEMBL142619 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YYZJJQLIOBCYAE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
421.6
MW (Da)
4.37
ALogP
7
HBA
1
HBD
72.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 4/cyclin D CHEMBL2095942 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 4/cyclin D | IC50 | = | 0.7 | nM | 9.15 | Inhibition of Cyclin-dependent kinase 4-cyclin D | 11101352 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11101352 | 10.1021/jm000271k | Cyclin-dependent kinase 4/cyclin D | 1 |
| 18468903 | 10.1016/j.bmc.2008.04.048 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine