Compound Detail
CHEMBL1434162
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1434162 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWCWUPRCWDSQEN-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
256.3
MW (Da)
2.96
ALogP
4
HBA
0
HBD
48.7
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.55
IC50 1 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Danio rerio CHEMBL613963 | EC50 | 6.55 | 6.55 | 280.0 | 1 |
| Tyrosinase CHEMBL1973 | IC50 | 5.08 | 5.08 | 8290.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Danio rerio | EC50 | = | 280.0 | nM | 6.55 | Lipid lowering activity in zebrafish embryos by Nile red fat metabolism assay | 29626799 |
| Tyrosinase | IC50 | = | 8290.0 | nM | 5.08 | Inhibition of Tyrosinase (unknown origin) using tyrosine as substrate incubated ... | 33242700 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29626799 | 10.1016/j.ejmech.2018.03.036 | Danio rerio | 4 |
| 33242700 | 10.1016/j.bmc.2020.115873 | Unchecked | 3 |
| 29626799 | 10.1016/j.ejmech.2018.03.036 | 3T3-L1 | 2 |
| 33242700 | 10.1016/j.bmc.2020.115873 | Tyrosinase | 2 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Bacillus cereus | 1 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Staphylococcus aureus | 1 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Escherichia coli | 1 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Moraxella catarrhalis | 1 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Cryptococcus neoformans | 1 |
| 22014830 | 10.1016/j.bmcl.2011.09.088 | Candida albicans | 1 |
Data from ChEMBL 36 via Core Engine