Compound Detail
CHEMBL1437764
CLIMBAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1437764 |
| Name | CLIMBAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
6
Known Names
Molecular Properties
292.8
MW (Da)
3.73
ALogP
4
HBA
0
HBD
44.1
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 5 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 7.0 | 5.66 | 100.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 5.35 | 5.35 | 4470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | IC50 | = | 100.0 | nM | 7.0 | null: A commercially available P450-GLO Assay kit (Promega Corporation, Madison ... | - |
| Cytochrome P450 3A4 | IC50 | = | 100.0 | nM | 7.0 | In vitro CYP3A4 Inhibition Assay: Cytochrome P450 is a large and diverse group o... | - |
| Unchecked | IC50 | = | 4470.0 | nM | 5.35 | Inhibition of transglutaminase in human keratinocytes in presence of 10 uM retin... | - |
| Cytochrome P450 3A4 | IC50 | = | 47500.0 | nM | 4.32 | null: Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at ... | - |
| Cytochrome P450 3A4 | IC50 | = | 47500.0 | nM | 4.32 | In vitro ATRA 4-Hydroxylase Activity Assay: All procedures were carried out unde... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent noradrenaline transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(3) dopamine receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Amine oxidase [flavin-containing] A | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Mu-type opioid receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent serotonin transporter | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Estrogen receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent dopamine transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine