Compound Detail
CHEMBL1447
LINCOMYCIN 💊 Approved Drug
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💊 Approved Drug
CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1
Basic Information
| ChEMBL ID | CHEMBL1447 |
| Name | LINCOMYCIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | OJMMVQQUTAEWLP-KIDUDLJLSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
20
Publications
6
Known Names
3
Indications
1
Mechanisms
Molecular Properties
406.6
MW (Da)
-0.86
ALogP
8
HBA
5
HBD
122.5
PSA (Ų)
0.37
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1964 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial 70S ribosome inhibitor | INHIBITOR | Bacterial 70S ribosome | ✓ | ✓ |
Indications
Bacterial Infections Multiple Sclerosis Osteomyelitis
ATC Classification
J01FF02
lincomycin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Drug Warnings
Black Box Warning
gastrointestinal toxicity
Black Box Warning
infectious disease
Activity Summary
Kd 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Albumin CHEMBL3253 | Kd | 4.92 | 4.92 | 12000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 2.1 | mL.min-1.kg-1 | Homo sapiens |
| F | 25.0 | % | Homo sapiens |
| Fu | 0.14 | - | Homo sapiens |
| MRT | 7.5 | hr | Homo sapiens |
| T1/2 | 5.6 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Albumin | Kd | = | 12000.0 | nM | 4.92 | Binding affinity to first site on human serum albumin by SPR | 19164148 |
Literature References
Data from ChEMBL 36 via Core Engine