Compound Detail
CHEMBL1464200
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1464200 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHPXYZMDLOJTFF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
234.2
MW (Da)
0.13
ALogP
6
HBA
3
HBD
143.8
PSA (Ų)
0.22
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA (cytosine-5)-methyltransferase 1 CHEMBL1993 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 CHEMBL3964 | IC50 | 5.4 | 5.4 | 3969.0 | 1 |
| RNA-editing ligase 1, mitochondrial CHEMBL4105928 | IC50 | 5.3 | 5.3 | 4989.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA (cytosine-5)-methyltransferase 1 | IC50 | = | 3200.0 | nM | 5.5 | PUBCHEM_BIOASSAY: Dose response confirmation of DNMT1 inhibitors in a Fluorescen... | - |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | IC50 | = | 3969.0 | nM | 5.4 | PubChem BioAssay. Counterscreen for inhibitors of phospholipase C isozymes (PLC-... | - |
| RNA-editing ligase 1, mitochondrial | IC50 | = | 4989.0 | nM | 5.3 | PubChem BioAssay. Fluorescence-based biochemical high throughput dose response a... | - |
Data from ChEMBL 36 via Core Engine