Compound Detail
CHEMBL14649
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Basic Information
| ChEMBL ID | CHEMBL14649 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NAUZZYIWKIXOQD-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
1.10
ALogP
5
HBA
2
HBD
93.5
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.32 | 6.32 | 476.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.14 | 6.14 | 730.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 5.9 | 5.9 | 1250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 476.0 | nM | 6.32 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA of rat cortical... | 10843235 |
| Glutamate NMDA receptor | IC50 | = | 730.0 | nM | 6.14 | Displacement of [3H]DCKA from N-methyl-D-aspartate glutamate receptor of rat cor... | 10843235 |
| Glutamate receptor ionotropic, kainate | IC50 | = | 1250.0 | nM | 5.9 | Inhibitory activity against generation of currents by 50 uM kainate in Xenopus o... | 10843235 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10843235 | 10.1016/s0960-894x(00)00181-5 | Mus musculus | 2 |
| 10843235 | 10.1016/s0960-894x(00)00181-5 | Glutamate receptor ionotropic, AMPA | 1 |
| 10843235 | 10.1016/s0960-894x(00)00181-5 | Glutamate NMDA receptor | 1 |
| 10843235 | 10.1016/s0960-894x(00)00181-5 | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine