Compound Detail
CHEMBL147138
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL147138 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHGGYEWCVWOGFX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
315.8
MW (Da)
4.04
ALogP
5
HBA
1
HBD
56.3
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.1 | 6.1 | 800.0 | 2 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 800.0 | nM | 6.1 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 800.0 | nM | 6.1 | Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorptio... | 21306896 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 11000.0 | nM | 4.96 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21306896 | 10.1016/j.bmcl.2011.01.037 | Vascular endothelial growth factor receptor 2 | 2 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Unchecked | 1 |
| 10639280 | 10.1021/jm990345w | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine