Assay Detail
Binding
CHEMBL811931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 uM of ATP.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433936 | — | — | 1 | 8.52 |
| CHEMBL440727 | — | — | 1 | 7.52 |
| CHEMBL421961 | — | — | 1 | 7.52 |
| CHEMBL150826 | — | — | 1 | 7.30 |
| CHEMBL25579 | — | — | 1 | 7.00 |
| CHEMBL147192 | — | — | 1 | 7.00 |
| CHEMBL127907 | — | — | 1 | 6.70 |
| CHEMBL24137 | — | — | 1 | 6.70 |
| CHEMBL150817 | — | — | 1 | 6.52 |
| CHEMBL357815 | — | — | 1 | 6.52 |
| CHEMBL151015 | — | — | 1 | 6.52 |
| CHEMBL147180 | — | — | 1 | 6.52 |
| CHEMBL434311 | — | — | 1 | 6.52 |
| CHEMBL286160 | — | — | 1 | 6.40 |
| CHEMBL150606 | — | — | 1 | 6.30 |
| CHEMBL356658 | — | — | 1 | 6.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | 6.16 |
| CHEMBL151942 | — | — | 1 | 6.10 |
| CHEMBL151067 | — | — | 1 | 6.10 |
| CHEMBL150187 | — | — | 1 | 6.10 |
| CHEMBL148869 | — | — | 1 | 6.05 |
| CHEMBL25610 | — | — | 1 | 5.96 |
| CHEMBL345943 | — | — | 1 | 5.92 |
| CHEMBL150657 | — | — | 1 | 5.82 |
| CHEMBL150315 | — | — | 1 | 5.70 |
| CHEMBL358672 | — | — | 1 | 5.09 |
| CHEMBL147138 | — | — | 1 | 4.96 |
| CHEMBL26050 | — | — | 1 | 4.82 |
| CHEMBL346200 | — | — | 1 | 4.66 |
| CHEMBL150581 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433936 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL440727 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL421961 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL150826 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL25579 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147192 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL127907 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL24137 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL357815 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL434311 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL147180 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL151015 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL150817 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL286160 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL356658 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL150606 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL151942 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL150187 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL151067 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL148869 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL25610 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL345943 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL150657 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL150315 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358672 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL147138 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL26050 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL346200 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL150581 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL150825 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL301018 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151418 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL151948 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347086 | — | IC50 | < | 2.0 | nM | - |