Compound Detail
CHEMBL147180
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Basic Information
| ChEMBL ID | CHEMBL147180 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MRGFIKKMPYGMGF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
416.9
MW (Da)
4.65
ALogP
6
HBA
1
HBD
59.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.03 | 5.03 | 9400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 40.0 | nM | 7.4 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 300.0 | nM | 6.52 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
| Fibroblast growth factor receptor 1 | IC50 | = | 9400.0 | nM | 5.03 | FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro. | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Unchecked | 1 |
| 10639280 | 10.1021/jm990345w | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine