Assay Detail
Binding
CHEMBL678320
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FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.06 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433936 | — | — | 1 | 5.85 |
| CHEMBL434311 | — | — | 1 | 5.82 |
| CHEMBL25579 | — | — | 1 | 5.80 |
| CHEMBL357815 | — | — | 1 | 5.75 |
| CHEMBL440727 | — | — | 1 | 5.60 |
| CHEMBL147192 | — | — | 1 | 5.58 |
| CHEMBL150187 | — | — | 1 | 5.21 |
| CHEMBL24137 | — | — | 1 | 5.17 |
| CHEMBL150315 | — | — | 1 | 5.16 |
| CHEMBL421961 | — | — | 1 | 5.16 |
| CHEMBL347086 | — | — | 1 | 5.13 |
| CHEMBL150817 | — | — | 1 | 5.03 |
| CHEMBL147180 | — | — | 1 | 5.03 |
| CHEMBL127907 | — | — | 1 | 4.96 |
| CHEMBL150825 | — | — | 1 | 4.85 |
| CHEMBL150657 | — | — | 1 | 4.80 |
| CHEMBL25610 | — | — | 1 | 4.72 |
| CHEMBL356658 | — | — | 1 | 4.70 |
| CHEMBL150606 | — | — | 1 | 4.60 |
| CHEMBL286160 | — | — | 1 | 4.57 |
| CHEMBL26050 | — | — | 1 | 4.40 |
| CHEMBL358672 | — | — | 1 | 4.35 |
| CHEMBL346200 | — | — | 1 | 4.24 |
| CHEMBL151948 | — | — | 1 | - |
| CHEMBL147138 | — | — | 1 | - |
| CHEMBL150826 | — | — | 1 | - |
| CHEMBL151015 | — | — | 1 | - |
| CHEMBL301018 | — | — | 1 | - |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | - |
| CHEMBL150581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433936 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL434311 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL25579 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL357815 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL440727 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL147192 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL150187 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL24137 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL150315 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL421961 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL347086 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL150817 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL147180 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL127907 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL150825 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL150657 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL25610 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL356658 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL150606 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL286160 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL26050 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL358672 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL346200 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL151948 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL147138 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150826 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL151015 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301018 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | > | 100000.0 | nM | - |
| CHEMBL150581 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL148869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151067 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL345943 | — | IC50 | > | 33000.0 | nM | - |