Compound Detail
CHEMBL150187
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Basic Information
| ChEMBL ID | CHEMBL150187 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAZIXFAROZCPDO-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
477.3
MW (Da)
4.09
ALogP
8
HBA
1
HBD
87.0
PSA (Ų)
0.43
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Fibroblast growth factor receptor CHEMBL2095217 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| HUVEC CHEMBL613979 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.21 | 5.21 | 6100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor | IC50 | = | 20.0 | nM | 7.7 | Inhibition of VEGFstimulated HUVEC cell proliferation | 10639280 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 40.0 | nM | 7.4 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Fibroblast growth factor receptor | IC50 | = | 100.0 | nM | 7.0 | Inhibition of FGF-stimulated HUVEC cell proliferation | 10639280 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 800.0 | nM | 6.1 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
| HUVEC | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of unstimulated HUVEC cell proliferation | 10639280 |
| Fibroblast growth factor receptor 1 | IC50 | = | 6100.0 | nM | 5.21 | FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro. | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor | 1 |
| 10639280 | 10.1021/jm990345w | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine