Assay Detail
Functional
CHEMBL690705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGF-stimulated HUVEC cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.04 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150187 | — | — | 1 | 7.00 |
| CHEMBL347086 | — | — | 1 | 6.10 |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | 5.82 |
| CHEMBL357815 | — | — | 1 | 5.77 |
| CHEMBL358672 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150187 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL347086 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL357815 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL358672 | — | IC50 | = | 3000.0 | nM | 5.52 |