Compound Detail
CHEMBL358672
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Basic Information
| ChEMBL ID | CHEMBL358672 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UGVYZLLHULWGLZ-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
405.4
MW (Da)
3.06
ALogP
9
HBA
1
HBD
110.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
| Fibroblast growth factor receptor CHEMBL2095217 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 5.09 | 5.09 | 8100.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.35 | 4.35 | 45000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 300.0 | nM | 6.52 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Vascular endothelial growth factor receptor | IC50 | = | 600.0 | nM | 6.22 | Inhibition of VEGFstimulated HUVEC cell proliferation | 10639280 |
| Fibroblast growth factor receptor | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of FGF-stimulated HUVEC cell proliferation | 10639280 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 8100.0 | nM | 5.09 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
| Fibroblast growth factor receptor 1 | IC50 | = | 45000.0 | nM | 4.35 | FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro. | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor | 1 |
| 10639280 | 10.1021/jm990345w | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine