Assay Detail
Functional
CHEMBL690866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFstimulated HUVEC cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor (CHEMBL2095227) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347086 | — | — | 1 | 8.40 |
| CHEMBL150187 | — | — | 1 | 7.70 |
| CHEMBL357815 | — | — | 1 | 7.40 |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | 7.30 |
| CHEMBL358672 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347086 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL150187 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL357815 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL358672 | — | IC50 | = | 600.0 | nM | 6.22 |