Assay Detail
Functional
CHEMBL690867
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Inhibition of unstimulated HUVEC cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.53 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150187 | — | — | 1 | 6.00 |
| CHEMBL347086 | — | — | 1 | 5.30 |
| CHEMBL357815 | — | — | 1 | 5.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | - |
| CHEMBL358672 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150187 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL347086 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL357815 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | > | 10000.0 | nM | - |
| CHEMBL358672 | — | IC50 | > | 10000.0 | nM | - |