Compound Detail
CHEMBL150825
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Basic Information
| ChEMBL ID | CHEMBL150825 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DUQXHJPGYOWVMD-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
377.8
MW (Da)
4.20
ALogP
6
HBA
1
HBD
65.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.0 | 6.64 | 10.0 | 3 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 4.2 | 4.2 | 63000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of KDR | 17306530 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1100.0 | nM | 5.96 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of KDR | 17306530 |
| Fibroblast growth factor receptor 1 | IC50 | = | 14000.0 | nM | 4.85 | FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro. | 10639280 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 63000.0 | nM | 4.2 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17306530 | 10.1016/j.bmcl.2007.01.089 | Vascular endothelial growth factor receptor 2 | 2 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Unchecked | 1 |
| 10639280 | 10.1021/jm990345w | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine