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Assay Detail

CHEMBL887535

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Binding
Inhibition of KDR
ChEMBL ↗
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pharmacophore modeling and in silico screening for new KDR kinase inhibitors.
Yu H, Wang Z, Zhang L, Zhang J, Huang Q.
Bioorg Med Chem Lett (2007) 17 : 2126 -2133
PubMed 17306530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 7.00 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL382979 — — 1 8.52
CHEMBL371329 — — 1 8.52
CHEMBL150826 — — 1 8.40
CHEMBL231139 — — 1 8.40
CHEMBL537435 — — 1 8.22
CHEMBL286160 — — 1 8.15
CHEMBL193306 — — 1 8.10
CHEMBL150825 — — 2 8.00
CHEMBL425749 — — 1 7.96
CHEMBL370545 — — 1 7.89
CHEMBL230413 — — 1 7.89
CHEMBL198297 — — 1 7.82
CHEMBL365318 — — 1 7.75
CHEMBL535 SUNITINIB 4.0 1 7.75
CHEMBL371510 — — 1 7.72
CHEMBL197353 — — 1 7.72
CHEMBL89363 — — 1 7.70
CHEMBL366241 — — 1 7.58
CHEMBL231649 — — 1 7.52
CHEMBL382517 — — 1 7.46
CHEMBL127907 — — 1 7.30
CHEMBL198267 — — 1 7.28
CHEMBL370325 — — 1 7.28
CHEMBL196747 — — 1 7.27
CHEMBL196020 — — 1 7.26
CHEMBL396219 — — 1 7.22
CHEMBL230081 — — 1 7.05
CHEMBL365178 — — 1 6.89
CHEMBL75034 — — 1 6.85
CHEMBL231650 — — 1 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL382979 — IC50 = 3.0 nM 8.52
CHEMBL371329 — IC50 = 3.0 nM 8.52
CHEMBL231139 — IC50 = 4.0 nM 8.40
CHEMBL150826 — IC50 = 4.0 nM 8.40
CHEMBL537435 — IC50 = 6.0 nM 8.22
CHEMBL286160 — IC50 = 7.0 nM 8.15
CHEMBL193306 — IC50 = 8.0 nM 8.10
CHEMBL150825 — IC50 = 10.0 nM 8.00
CHEMBL425749 — IC50 = 11.0 nM 7.96
CHEMBL230413 — IC50 = 13.0 nM 7.89
CHEMBL370545 — IC50 = 13.0 nM 7.89
CHEMBL198297 — IC50 = 15.0 nM 7.82
CHEMBL365318 — IC50 = 18.0 nM 7.75
CHEMBL535 SUNITINIB IC50 = 18.0 nM 7.75
CHEMBL371510 — IC50 = 19.0 nM 7.72
CHEMBL197353 — IC50 = 19.0 nM 7.72
CHEMBL89363 — IC50 = 20.0 nM 7.70
CHEMBL366241 — IC50 = 26.0 nM 7.58
CHEMBL231649 — IC50 = 30.0 nM 7.52
CHEMBL382517 — IC50 = 35.0 nM 7.46
CHEMBL127907 — IC50 = 50.0 nM 7.30
CHEMBL198267 — IC50 = 53.0 nM 7.28
CHEMBL370325 — IC50 = 52.0 nM 7.28
CHEMBL196747 — IC50 = 54.0 nM 7.27
CHEMBL196020 — IC50 = 55.0 nM 7.26
CHEMBL396219 — IC50 = 60.0 nM 7.22
CHEMBL230081 — IC50 = 90.0 nM 7.05
CHEMBL365178 — IC50 = 130.0 nM 6.89
CHEMBL75034 — IC50 = 140.0 nM 6.85
CHEMBL231650 — IC50 = 150.0 nM 6.82
CHEMBL276711 SEMAXANIB IC50 = 200.0 nM 6.70
CHEMBL75077 — IC50 = 240.0 nM 6.62
CHEMBL193256 — IC50 = 270.0 nM 6.57
CHEMBL364962 — IC50 = 270.0 nM 6.57
CHEMBL77555 — IC50 = 300.0 nM 6.52
CHEMBL410186 — IC50 = 380.0 nM 6.42
CHEMBL74143 — IC50 = 650.0 nM 6.19
CHEMBL306707 — IC50 = 870.0 nM 6.06
CHEMBL388936 — IC50 = 1000.0 nM 6.00
CHEMBL150825 — IC50 = 1100.0 nM 5.96
CHEMBL433321 — IC50 = 1400.0 nM 5.85
CHEMBL306284 — IC50 = 1700.0 nM 5.77
CHEMBL150581 — IC50 = 2700.0 nM 5.57
CHEMBL230520 — IC50 = 2900.0 nM 5.54
CHEMBL370006 — IC50 = 4600.0 nM 5.34
CHEMBL230414 — IC50 = 15400.0 nM 4.81
CHEMBL321359 — IC50 = 20000.0 nM 4.70
CHEMBL396788 — IC50 = 31000.0 nM 4.51