Compound Detail
CHEMBL537435
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Basic Information
| ChEMBL ID | CHEMBL537435 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PPAOSJDRUASTHP-UHFFFAOYSA-N |
| Parent Compound | CHEMBL371329 |
| Active Moiety | CHEMBL371329 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
389.5
MW (Da)
5.20
ALogP
5
HBA
3
HBD
92.9
PSA (Ų)
0.45
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of KDR | 17306530 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17306530 | 10.1016/j.bmcl.2007.01.089 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine