Compound Detail
CHEMBL321359
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Basic Information
| ChEMBL ID | CHEMBL321359 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WSUCIBGSTGQSRL-FMIVXFBMSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
224.3
MW (Da)
2.52
ALogP
2
HBA
1
HBD
34.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL3337 | IC50 | 4.69 | 4.69 | 20417.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of KDR | 17306530 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 20417.38 | nM | 4.69 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | 10956210 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10956210 | 10.1021/jm990609e | Vascular endothelial growth factor receptor 2 | 1 |
| 17306530 | 10.1016/j.bmcl.2007.01.089 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine