Assay Detail
Binding
CHEMBL811926
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Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL3337) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
DoMCoSAR: a novel approach for establishing the docking mode that is consistent with the structure-activity relationship. Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.47 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103211 | — | — | 1 | 7.15 |
| CHEMBL320186 | — | — | 1 | 6.85 |
| CHEMBL323523 | — | — | 1 | 6.74 |
| CHEMBL89483 | — | — | 1 | 6.52 |
| CHEMBL101797 | — | — | 1 | 6.41 |
| CHEMBL323085 | — | — | 1 | 6.15 |
| CHEMBL104330 | — | — | 1 | 6.15 |
| CHEMBL296455 | — | — | 1 | 6.10 |
| CHEMBL330321 | — | — | 1 | 6.00 |
| CHEMBL105739 | — | — | 1 | 5.98 |
| CHEMBL90277 | — | — | 1 | 5.68 |
| CHEMBL441641 | — | — | 1 | 5.63 |
| CHEMBL321797 | — | — | 1 | 5.60 |
| CHEMBL89040 | — | — | 1 | 5.60 |
| CHEMBL103307 | — | — | 1 | 5.57 |
| CHEMBL104908 | — | — | 1 | 5.57 |
| CHEMBL431025 | — | — | 1 | 5.52 |
| CHEMBL89809 | — | — | 1 | 5.52 |
| CHEMBL102770 | — | — | 1 | 5.52 |
| CHEMBL101022 | — | — | 1 | 5.47 |
| CHEMBL421548 | — | — | 1 | 5.39 |
| CHEMBL89723 | — | — | 1 | 5.37 |
| CHEMBL418799 | — | — | 1 | 5.35 |
| CHEMBL103788 | — | — | 1 | 5.34 |
| CHEMBL315546 | — | — | 1 | 5.29 |
| CHEMBL321781 | — | — | 1 | 5.13 |
| CHEMBL318788 | — | — | 1 | 5.12 |
| CHEMBL102519 | — | — | 1 | 5.07 |
| CHEMBL321359 | — | — | 1 | 4.69 |
| CHEMBL323133 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103211 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL320186 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL323523 | — | IC50 | = | 181.97 | nM | 6.74 |
| CHEMBL89483 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL101797 | — | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL323085 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL104330 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL296455 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL330321 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL105739 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL90277 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL441641 | — | IC50 | = | 2344.23 | nM | 5.63 |
| CHEMBL89040 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL321797 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL104908 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL103307 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL431025 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL89809 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL102770 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL101022 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL421548 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL89723 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL418799 | — | IC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL103788 | — | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL315546 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL321781 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL318788 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL102519 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL321359 | — | IC50 | = | 20417.38 | nM | 4.69 |
| CHEMBL323133 | — | IC50 | = | 22387.21 | nM | 4.65 |
| CHEMBL85403 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL328452 | — | IC50 | = | 40738.03 | nM | 4.39 |
| CHEMBL321966 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL87080 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL89697 | — | IC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL88405 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL314798 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL100955 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL103212 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL86326 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL102450 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL317660 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL317867 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL86432 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL312826 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL86944 | — | IC50 | = | 1000000.0 | nM | - |